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Title   두경부 선양낭성암종에서의 P27Kip1 , Ki-67 과 Bc1-2 표현 양상에 관한 연구 ( p27Kipl , K-67 and Bcl-2 Expression in Adenoid Cystic Carcinoma of Head and Neck )
Publicationinfo   2000 Jan; 032(02): 382-390.
Key_word   Head and neck neoplasm adenoid cystic carcinoma, p27Kip1 , Ki-67, Bcl-2
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Abstract   Purpose: p27Kip1 negatively regulates cell proliferation by mediating cell cycle arrest in Gl and Ki-67 is a reliable cellular proliferative index. Also Bcl-2, an inhibitor of apoptosis, has potential activity toward cell survival. The present study investigated p27Kip1, Ki-67 and Bcl-2 expression in adenoid cystic carcinoma for their usefulness of indicator in tumor progression and aggressiveness. Materials and Methods: Formalin-fixed paraffin-embedded surgical specimens were obtained from seventeen patients with adenoid cystic carcinoma. We performed immunohistochemical staining with p27Kip1, Ki-67 and Bcl-2 monoclonal antibodies and compared with patients clinicopathologic features. Results: There were significant correlation between low p27Kip1 expression and high grade and T classification, positive nodal status and perineural invasion and high stages. However, Ki-67 and Bcl-2 expression had no significant differences in clinicopathologic features and p27Kip1 expression. Conclusion: p27Kip1 is a good reliable marker of tumor progression and aggressiveness in adenoid cystic carcinomas.
저 자   최충식(Choong Sik Choi),최건(Geon Choi),송재준(Jae Joon Song),황규성(Kyu Sung Hwang),정광윤(Kwang Yoon Jung),최종욱(Jong Ouck Choi)